Once you place Hel rune, the socketed item, and a Scroll of Town Portal inside Horadric Cube, and press Transmute button, you will get a fresh version of the item or gear with all gems, runes, and jewels removed. Apart from Charms, you can use the cube to hold other items during your runs in D2R. But the main thing to keep in mind is that, if you keep any Charms inside the Horadric Cube, they will not give any extra effects or properties to change your stats. It might feel hectic to always open and close the Horadric Cube to move items to and fro, but it’s well worth it. This item takes up 4 spaces in your inventory, but you can open it up to get 12 additional inventory spaces. Horadric Cube can also be used to increase the inventory size in Diablo 2 Resurrected. Once you complete the quest you will get the Horadric Cube as one of the quest rewards along with other items. You will be visiting this area during the Act 2 main quest “The Horadric Staff”, where Deckard Cain will ask you to create the Horadric Staff.

Halls of the Dead location will be in Dry Hills, an area adjacent to Rocky Waste in Diablo 2 Resurrected. You can find and get the Horadric Cube item from the bottom third level floor of the Halls of the Dead dungeon. To unsocket and remove socketed gems, jewels, or runes from items and gears in Diablo 2 Resurrected, you need to unlock Horadric Cube in Halls of the Dead dungeon in the Dry Hills during Act 2 to use a Hel rune, a Scroll of Town Portal, and the socketed item, and then click on the Transmute button.

Diablo 2 resurrected cube socket recipe